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Title: Association Between 25(OH)D Serum Levels with Calcaneus Bone Mass Density in Elderly at Rural Public Health Care Clinics of Jakarta Islamic State University in 2017
Authors: Achmad Zaki
Fika Ekayanti
Flori R Sari
Amalina Fitrasari
Ning Indah
Nurhayati Adnan
Sudarto Ronoatmodojo
Keywords: 25(OH)D;calcium;bone mass density;osteoporosis;elderly
Issue Date: 2017
Publisher: International Journal Advances in Health Sciences Research - Atlantic Press
Abstract: Osteoporosis is systemic bone disease marked by decline of bone mass density (BMD) and deterioration of bone microarchitecture so that bones become brittle and break easily. With the increasing of life expectancy, number of elderly in Indonesia will increase simultaneously. Estimated 10% of Indonesian population at the year 2020 will be above 60 yo. These elderly population risk developing degenerative disease such as osteoporosis. Serum 25(OH)D and calcium level regulated along with bone calcium deposit by hormonal signals dynamics. To identify the relationship between serum 25(OH)D and calcium level with calcaneus BMD in elderly at rural area. This study use analytic cross-sectional design conducted at KPKM Reni Jaya UIN Syarif Hidayatullah Jakarta in February-Mei 2017 with consecutive sampling. Calcium and 25(OH)D level obtained from peripheral blood serum while calcaneus BMD was measured using Hologic Sahara Quantitative Ultrasound. Respondent were given informed consent before enrolled in this study. Data were checked for variance and normality using boxplot, histogram, kurtosis and skewness ratio before undergoing statistical analysis using RealStats add in for Microsoft Excell 2016. Data gathered from 60 respondent shows a prevalence of 68.3% BMD classified as osteoporosis which was significantly (p<0.05) dominated by women (53.3%). Statistical analysis shows a significant association (p<0.05) between low level of serum 25(OH)D and BMD. Respondent weight also shows significant association (p<0.05) although, no significant association shown between Body Mass Index and BMD. Low level of serum calcium also shows significant association (p<0.05) toward BMD condition. Binary logistic regression analysis shows that serum calcium level significantly alter probability of developing osteoporotic BMD appearance in elderly. The serum pre-hormone 25(OH)D and calcium deficiency related to the deterioration of calcaneus bone mass density in osteoporosis condition. Development of osteoporosis most likely occurred to elderly women with a low serum calcium and vitamin D level.
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