Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/50748
Title: Antidiabetic effect and glucose tolerance of areca nut (Areca catechu) seed ethanol extract on alloxan-induced diabetic male rats
Other Titles: "The 3rd International Conference on Natural Products and Bioresource Sciences 2019 (ICONPROBIOS 2019)"
IOP Conference Series: Earth and Environmental Science Volume 462, 2020
Authors: Muhammad Yanis Musdja
Aris Nurdin
Ahmad Musir
Keywords: Prosiding Terindeks SCOPUS;Areca catechu as Anti-diabetes
Issue Date: 15-Apr-2020
Publisher: IOP Conference Series: Earth and Environmental Science (SCOPUS)
Series/Report no.: Vol: 462, 2020;012036
Abstract: Areca catechu fruit (Areca nut) is one component of betel chewing. There is an assumption that the antidiabetic effect of chewing betel is sourced from areca nut. This study aims to determine the anti-hyperglycemic effect and glucose tolerance of ethanol extract of areca nut (Areca catechu) seed in diabetic rats. Old Areca nut fruit was obtained from a garden in the Depok region, the suburb of Jakarta. Areca nut seeds were made into a fine powder, then macerated by using 70% ethanol at room temperature based on the Harbone method. Male rats were eligible for the trial; after acclimatization, rats were made diabetic by using alloxan. The rats for this trial were divided into 6 groups. Each of groups consisted of 5 rats. Glibenclamide was used as a positive control for anti-diabetic, and acarbose was used for glucose tolerance test, as normal control was given distilled water, while negative control was used 1% CMC Na, namely a solution suspending agent for test preparation. Areca nut seed extract was given with 3 types of doses, namely low, medium and high doses, namely 22.5 mg; 45 mg and 180 mg per 200 gr body weight (BW) rats, respectively. For measure blood, sugar levels were used as a glucometer tool. The result of this study showed that on 14 days of given test preparation, the statistical results with ANOVA test and Kruskal-Wallis test showed that medium doses of areca nut seed extract had the same anti-diabetic effect and glucose tolerance with positive control and were significantly different to negative controls. (P≤0.05). While on the low and high dose was not significantly different from negative controls (P≥0.05). Conclusion of this study, areca nut seed was very potential for antidiabetic and glucose tolerance.
Description: This study aims to determine the anti-hyperglycemic effect and glucose tolerance of ethanol extract of areca nut (Areca catechu) seed in diabetic rats.
metadata.dc.description.uri: https://iopscience.iop.org/article/10.1088/1755-1315/462/1/012036/pdf
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/50748
ISSN: 1755-1315
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