Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/48924
Title: ACTIVITY TEST OF CATECHINS ISOLATE OF GAMBIR (UncariagambirRoxb) ON BURN WOUND HEALING OF MALE WHITE RAT (Rattusnorvegicus)
Other Titles: The 2nd International Conference on Medical Chemistry
Authors: Muhammad Yanis Musdja
Lina Elvita
Nursetyowati Rahayu
Keywords: International Seminar;Pharmacy
Issue Date: 6-Oct-2017
Publisher: Bandung Institute of Technology (ITB)
Series/Report no.: The 2nd International Conference On Medicinal Chemistry ITB;OP-21
Abstract: Background: Indonesia is the largest gambir Uncaria gambir Roxb producing country in the world, but its benefits as a medicinal plant has not been optimally developed Traditionally, gambir plants have been widely used by the community as wound healers There are allegations of gambir efficacy as a wound healer because its content of the main substance catechins Objective This study aims to determine the efficacy of catechin isolate as a healing burn on white rats Rattus norvegicus male Sprague Dawley strain through observation of anatomical and histopathological pathology Methods Catechins of gambir were isolated by using partition method with ethyl acetate solvent Rats were made to suffer burns with Akhoondinasab method, et al A total of 30 male white rats were divided into 5 groups, given daily test preparations A total of 3 groups were given catechin isolates prepared by gel with variations of concentrations of 1 2 and 4 One group was used as a comparison with a patent medicine for healing burns and one other group was used as a negative control After administration of the dosage for 21 days, the pathology and histology changes was observed in the burns that occurred Results Statistical analysis using one way ANOVA and Kruskal Wallis showed that gel isolate catechins Gambir with concentrations 2 showed the effect of decreasing the burn area and an increase in the percentage of healing of burns that do not differ significantly from positive controls (P 0 05 Histopathologic observations showed that gambir catechin isolates were able to reduce the number of inflammatory cells and increase neocapillary formation compared with the negative control group Conclusion Catechin isolates of gambir with concentration 2 can help the healing process of second degree of burns in the inflammatory phase and proliferation Key words Gambir Catechins isolate, burns, healing
Description: Objective This study aims to determine the efficacy of catechin isolate as a healing burn on white rats Rattus norvegicus male Sprague Dawley strain through observation of anatomical and histopathological pathology
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/48924
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar

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