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Title: The activity test of ethanol extract of elephantopus scaber linn to decrease blood uric acid levels in male rats
Other Titles: 2nd International Conference of Herbal Medicine 2018,
Authors: Muhammad Yanis Musdja
Abdul Arief Azter
Ahmad Musir
Keywords: International Seminar;Pharmacy
Issue Date: 5-Sep-2018
Publisher: Universitas YARSI
Series/Report no.: PROGRAM BOOK;Herbal Medicine
Abstract: Traditionally Elephantopus scaber Linn leaf is used for treatment of various ailments like, diarrhea nephritis, pain in the chest, cough, sca-bies, edema, arthralgia, rheumatoid arthritis, bladder stones and joint pain, as folk medicine. The aim of the present study is to prove the effect of E. scaber leaf to decrease uric acid levels in blood serum male rats. The E. scaber leaf was obtained from Balitro Bagor, Indonesia. Preparation of E. scaber leaf extract was done by cold maceration extraction technique using ethanol 70%. Male rats (Sprague-Dawley) were made into increase uric acid by using caffeine with dose 27 mg/200 g b.w. Rats were divided into 6 groups, as a positive control was used allopurinol 36 mg/200 g b.w, as a handling control was used caffeine 27 mg/kg b.w suspended in Na-CMC 0.5%, as normal control was used Na-CMC 0.5% and for test preparation were used 3 doses, i.e, 175 mg/200 g b.w, 350 mg/200 g b.w and 700 mg/200 b.w. The result of a decrease blood uric acid levels in rats, on the 15th days showed that a dose of 350 mg / 200 g b.w gave decrease the high-est percentage ie 43%. Statistical analysis on the 15th day with one-way ANOVA and LSD test showed that all of the test preparation groups of E. scaber had effects decrease uric acid in blood serum of rats and significantly different from negative controls (p ≤ 0.05). The dose 350 mg/200 g b.w of E. scaber. The dose of 350 mg/200 g b.w of E. scaber L had the same effect with a dose of 36 mg/200 g b.w allopurinol in reducing uric acid in experimental rats.. Keywords: Elephantopus scaber, gout, join pain, rat, uric acid.
Description: The aim of the present study is to prove the effect of E. scaber leaf to decrease uric acid levels in blood serum male rats.
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar

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15. ORAL SEM INT - THE ACTIVITY TEST (REP-UIN-5-Sep-2018).pdf1.19 MBAdobe PDFView/Open
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