Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/48910
Title: Effects of Catechins Isolate of uncaria gambir roxb on burn wound healing in male rats
Other Titles: Bromo Conference Symposium on Natural Products & Biodiversity Interntional Conference 2018
Authors: Muhammad Yanis Musdja
Lina Elvita
Nursetyowati Rahayu
Keywords: International Seminar;Pharmacy
Issue Date: 12-Jul-2018
Publisher: Faculty of Pharmacy, Airlangga University
Series/Report no.: Symposium Natural Products &Biodiversity;Gambir for Wound Healing
Abstract: Background. Indonesia is the largest Uncaria gambir, Roxb (gambir) producing country in the world, but its benefits as a medicinal plant has not been optimally developed. Traditionally, gambir plants have been widely used by the community as wound healers. Objective: This study aims to determine the efficacy of catechin isolate as a healing burn on white rats male Sprague Dawley strain through observation of anatomical and histopathological pathology. Methods: Catechins of gambir were isolated by using partition method with ethyl acetate solvent. Rats were made to suffer burns with Akhoondinasab method, et al. A total of 30 male white rats were divided into 5 groups, given daily test preparations. A total of 3 groups were given catechin isolates prepared by gel with variations of concentrations of 1%, 2% and 4%). One group was used as a comparison with a patent medicine for healing burns and one other group was used as a negative control. After administration of the dosage for 21 days, the pathology and histology changes was observed in the burns that occurred. Results: Statistical analysis showed that gel isolate catechins of Gambir with concentrations 2% showed the effect of decreasing the burn area and an increase in the percentage of healing of burns that do not differ significantly from positive controls (P <0.05). Histopathologic observations showed that gambir catechin isolates were able to reduce the number of inflammatory cells and increase neocapillary formation compared with the negative control group. Conclusion: Catechin isolates of gambir with concentration 2 % can help the healing process of second degree of burns in the inflammatory phase and proliferation. Key words : Uncaria gambir, Catechins isolate, burn wound healing, male rats
Description: This study aims to determine the efficacy of catechin isolate as a healing burn on white rats male Sprague Dawley strain through observation of anatomical and histopathological pathology.
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/48910
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar

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7. ORAL SEM INT - EFFECT OF CATECHIN (REP-UIN-12-JUL-2018).pdf1.18 MBAdobe PDFView/Open
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