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Other Titles: Proceeding of The 2nd International Conference on Pharmacy and Advanced Pharmaceutical Sciences, Faculty of Pharmacy, UGM
Authors: Muhammad Yanis Musdja
Amir Syarif
Ernie Hernawati Poerwaningsih
Andria Agusta
Keywords: International Proceeding;PP 76 - 81;Oral Presentation
Issue Date: 19-Jul-2011
Publisher: Faculty of Pharmacy, Universitas Gajah Mada
Series/Report no.: The 2nd International Conference on Pharmacy and Advanced Pharmaceutical Sciences;
Abstract: The mixture of betel leaf (Piper betle L), gambier (Uncaria gambir, Roxb) and slaked lime (calcium hydroxide) has been used as one of traditional medicine in Indonesia and other countries with multipurpose for a long time. Generally, the mixture of extract is used for chewing in their natural raw condition along with many other ingredients like betel, areca nut, Gambier, cardamom, slaked lime, etc. some people use it as an immunomodulatory agent. To ensure the effectiveness of the mixture of betel chewing as an immunomodulatory agents. Materials and a mixture that consists of water extract of betel leaves, Gambier and slaked lime, the extract was given to 7 groups of mice for 14 days with doses 100, 200 and 400 m/kg body weight. Two kinds of Immunomodulatory drug in syrup form commonly used in the treatment of infectious was used as positive controls. Then the peritoneal fluid of mice containing macrophage cells was isolated by performing surgery. This study calculated the number of phagocytosis activity and capacity of macrophage cells of mice, after one hour intra peritonial injection Staphyloccosus epidermidis on each group of mice. The betel chewing component mixture group compared with negative controls showed an increase of phagocytosis activity of 86.6%, 94.2% and 88.3% for doses of 100, 200 and 400 mg/kg body weight, respectively. Meanwhile the phagocytosis capacity was found for an average of 50 macrophage cells was 626.1, 806.4 and 754.5 bacteria for dose of 100, 200 and 400 mg/kg body weight respectively. For the doses administered the 200 mg/kg dose showed the most efficacy where both the phagoytic activity and capacity was calculated statistically significant (p≤0.05) Key words: Immunomodulatory, betel, gambier, slaked lime.
Description: The mixture of betel leaf (Piper betle L), Gambier (Uncaria gambir, Roxb) and slaked lime (calcium hydroxide) has effect as immunomodulatory agent. Dose of 200 mg/kg body weight is better than dose of 100 mg / kg and dose of 400 mg/kg body weight.
ISBN: 978-979-955-1
Appears in Collections:Publisher Version

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