Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/47569
Title: Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats
Other Titles: Proceedings of BROMO 2018.
Authors: Muhammad Yanis Musdja
Lina Elvita
Nursetyowati Rahayu
Keywords: International Proceeding;DOI: 10.5220/0008361002610271
Issue Date: 11-Nov-2018
Publisher: SCITEPRESS – Science and Technology Publications, Lda. All rights reserved.
Series/Report no.: In Proceedings of BROMO Conference (BROMO 2018),;pages 261-271
Abstract: Abstract: Background: Indonesia is the largest Uncaria gambir, Roxb (gambir) producing country in the world, but its benefits as a medicinal plant has not been optimally developed. Traditionally, gambir plants have been widely used by a lot of people as burn wound healing. Objective: This study aims to determine the effect of gambir catechins crude for burn wound healing through histopathological observations on white rats male. Methods: Gambir Catechins crude was isolated by using partition method with ethyl acetate solvent. The rats were made to suffer burn wound based on Akhoondinasab methods et al. A total of 30 male white rats were divided into 5 groups and given daily test preparations. A total of 3 groups were given gambir catechins crude gel with variations of concentrations of 1%, 2% and 4%), for positive control group was used a commercial drug that contains 10% placenta extract and 0.5% Neomycin sulfate and one other group was used as a negative control. After administration of test preparation for 21 days, histopathology changes was observed in the burn wound that occurred. Results: Statistical analysis showed that gel gambir catechins crude with concentrations 2% had effect of decreasing the burn wound area and an increase in the percentage of healing of burn wound that did not differ significantly from positive controls (P <0.05). Histopathologic observations showed that catechins crude of gambir were able to reduce the number of inflammatory cells and increase neocapillary formation compared with the negative control group. Conclusion: Gambir catechins crude with concentration 2 % could help the healing process of second degree of burn wound on the inflammatory phase and proliferation. Keywords: Catechins, burn wound healing, male rats Uncaria gambir,
Description: This study aims to determine the effect of gambir catechins crude for burn wound healing through histopathological observations on white rats male.
metadata.dc.description.uri: https://www.scitepress.org/SearchResults.aspx?Context=lPd8P7vEQgE=&t=1
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/47569
ISBN: 978-989-758-347-6
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar



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