Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/47471
Title: EFFECT OF ETHANOL EXTRACT OF FOENICULUM VULGARE MILL ON INHIBITION OF URIC ACID CRYSTALS FORMATION IN MALE RATS
Other Titles: INTERNATIONAL RESEARCH JOURNAL OF PHARMACY
Authors: Muhammad Yanis Musdja
Dewa Asmara
Ahmad Musir
Keywords: International Journal;Scopus Index;Volume 10, Issue 1;JANUARY 2019
Issue Date: 3-Jan-2019
Publisher: INTERNATIONAL RESEARCH JOURNAL OF PHARMACY
Series/Report no.: International Research Journal Of Pharmacy;Volume 10, Issue 1, JANUARY 2019
Abstract: ABSTRACT In traditional medicine Foeniculum vulgare Mill (fennel) is used for treatment as antioxidant, anti-cancer activity, anti-inflammatory, antifungal, anti-bacterial and estrogenic effects which are probably due to the presence of aromatic compounds such as anethole, estragole and fenshon. Some people, used it for the treatment in gout disease. The purpose of this study was to determine the effect of fennel seed in reducing uric acid levels in serum of male rats. The fennel seed was obtained from Balitro Bagor, Indonesia. Preparation of fennel seed extract was done by cold maceration extraction technique using ethanol 70%. To increase uric acid levels in blood serum, the rats were induced by using caffeine with dose 27 mg/200 g b.w. The rats were divided into 6 groups. In positive control, allopurinol 36 mg/200 g b.w was used. To increase uric acid levels in rat blood, caffeine 27 mg/kg b.w was used. Test preparation was suspended in Na-CMC 0.5%. For test preparation 3 doses were used, i.e, 75 mg/200 g b.w, 150 mg/200 g b.w and 300 mg/200 b.w. Increase in blood uric acid levels was done by inducing caffeine 27 mg/200 g b.w in rats. The blood uric acid levels of the rats were measured on the 6th day in order to ensure that caffeine with such doses causes hyperuricemia. On the 7th day, treatment was given to each group per day and caffeine was also given to all groups except the normal group. Measurement of blood uric acid levels were done on the day 9th, 12th and 15th. Statistical analysis on the 15th day with one-way ANOVA and Least Significant Difference (LSD) test showed that all of the test preparation groups of fennel seeds decreased uric acid. Optimum results were obtained on day 15th with decreased uric acid levels for positive control at the doses of 75 mg/200 g b.w, 150 mg/200 g b.w and 300 mg/200 g b.w with 58.63%, 50.84%, 40.25% and 43.69% respectively and significantly different from the negative control (p≤0,05), while the decrease effect of dose of 75 mg / 200 g b.w with positive control was not significantly different (p≥0,05). Keywords: Fennel, Foeniculum vulgare, gout, join pain, rat, uric acid.
Description: The purpose of this study was to determine the effect of fennel (Foeniculum vulgare Mill) seed in reducing uric acid levels in serum of male rats
metadata.dc.description.uri: https://irjponline.com/admin/php/uploads/3194_pdf.pdf
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/47471
ISSN: 2230-8407
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