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Title: Nigella Sativa as an Anti-Inflammatory Agent in Asthma
Authors: Mukhtar Ikhsan
Nurul Hiedayati
Kazutaka Maeyama
Fariz Nurwidya
Keywords: Wistar Rat
Issue Date: Oct-2018
Publisher: BMC Research Note
Series/Report no.: BMC Research Notes;30340634
Abstract: Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Histamine concentration was measured by high performance liquid chromatography-fluorometry. The study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.
Description: Article
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