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Title: Analisis Bioinformatika Gen Sitoglobin Manusia
Authors: Endah Wulandari
Keywords: bioinformatic, Cygb, human, gene, hypoxia
Issue Date: May-2015
Publisher: UIN Syarif Hidayatullah Jakarta: Fakultas Kedokteran dan Ilmu Kesehatan, 2015
Abstract: Background: bioinformatics analysis on gene sitoglobin (Cygb) is a computerized and informatics knowledge that to understand the mechanism of human Cygb the body at molecular level. Analysis Cygb that we wants to know is the structural analysis, the analysis of interactions with other proteins and molecules, the analysis Phylogenetics has new knowledges about Cygb (sequences, DNA variations, location, expression, modification, structure and clinical data). We can get a predictions of some data Cygb data (restriction site mapping, exon-intron regions, regions antigen, function, gene identification and design primers design). Methods: We use NCBI web site, OMIM, SNIP, uniprot, BLAST, PsiPred, Expasy, TMHMM, Prot Model, PyMOL, SignalP and PerlPrimer software. Results: Cygb is a hexacoordinate globin superfamily (hxHb). It has the homology with some species, 190 amino acids (20.9 kDa). The location of chromosome human cygb in 17q25, there are 4 exons and 3 introns, in residues 81 and 113 bonded to metals Fe. The protein target in the cytoplasm. It has 14 known mutations (7 silents and 7 missense). However, the mutations of ygb doesn’t have clinical impact, but it is get variation of molecules weight, peptides location and activity some scale cutting of amino acids sequensce. At Cygb mutations which has have the same glycosylation sites, doesn’t affect the catalytic site of Cygb to binding Fe and oxygen. Conclusion: Cygb a globin protein family that is contained in all tissues on offer in the cytoplasm, whose appearance caused by hypoxia which serve to supply oxygen.
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