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Title: Epoxide hydrolase polymorphisms and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study
Authors: Hoirun Nisa
Keywords: Cancer genetics;Colorectal cancer;Smoking
Issue Date: 4-Oct-2011
Publisher: Japanese Cancer Association
Series/Report no.: Proceedings of the 70th Annual Meeting of the Japanese Cancer Association;
Abstract: We investigated the relation the relation of polymorphisms in exon 3 (Y113H) and exon 4 (H139R) of the Epoxide Hydrolase 1 (EPHX1) with the colorectal cancer risk, and the interaction between these polymorphisms and cigarette smoking on the risk of colorectal cancer. We used data from Fukuoka Colorectal Cancer Study, a population-based case-control study, including 685 cases and 778 controls who gave informed consent to genetic analysis. Interview was conducted to assess lifestyle factors, and DNA was extracted from buffy coat. Neither of the two polymorphisms was associated with the risk of colorectal cancer. Odds ratios of colorectal cancer for predicted intermediate and high EPHX1 activities in comparison with predicted low EPHX1 activity were 1.03 (95% confidence interval, 0.81-1.30) and 0.92 (0.67-1.25), respectively. No interaction between EPHX1 polymorphisms or the combination of EPHX1 polymorphisms and cigarette smoking on colorectal cancer risk was shown. These findings suggest that EPHX1 polymorphisms do not play an important role in colorectal carcinogenesis.
Description: Oral presentation in the 70th Annual Meeting of the Japanese Cancer Association (JCA), 3-5 October 2011, Nagoya Congress Center, Nagoya, Japan
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar

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