Please use this identifier to cite or link to this item: http://repository.uinjkt.ac.id/dspace/handle/123456789/32058
Title: A Case-Control Study of Colorectal Cancer in Relation to Lifestyle Factors and Genetic Polymorphisms: Design and Conduct of Colorectal Cancer Study in Jakarta
Authors: Hoirun Nisa
Keywords: Colorectal cancer;Lifestyle;Diet;Genetic polymorphism
Issue Date: 21-Oct-2015
Publisher: Faculty of Public Health Universitas Indonesia
Series/Report no.: Proceeding of the 47th Asia Pacific Academic Consortium for Public Health Conference;
Abstract: Background. Colorectal cancer is an emerging public health problem in Indonesia and currently ranks among the three highest cancers. Lack of a colonoscopy screening and lifestyle changes might contribute to it. Only few studies have investigated the effect of lifestyle, diet, and genetic polymorphisms to colorectal carcinogenesis in Indonesia, and the results are conflicting. We assess the roles of dietary and other behavioral influences, in combination with genetic polymorphisms, in colorectal carcinogenesis. We also examine the role of religious guidance for colorectal patients in Fatmawati hospital. Methods. We use a community-based case-control study, consisting of 50 cases and 168 controls. Both cases and controls are residents in Jakarta and two stabling areas of State Islamic University Jakarta. Cases are patients undergoing surgery for the first diagnosis of colorectal cancer at Fatmawati hospital, and controls are participants of health screening for non communicable disease , selected by frequency-matching with respect to the expected distribution by sex, age (10-year class), and residence. Dietary and other lifestyle factors are ascertained by in-person interview, and venous blood is obtained for genotyping and possible biochemical measurements. Informed consents are collected from the participants for genetic analysis. The study is still ongoing. Results. Results of this study will explain the etiology of colorectal cancer disease specific to the people of Indonesia in conjunction with lifestyle factors, diet, genetic polymorphisms and interactions between genetic polymorphisms and lifestyle factors in colorectal carcinogenesis. The role of religious guidance information during the treatment is expected to be a reference for non-medical measures to prevent the severity of the disease. Conclusion. Results of the study will discover how lifestyle, diet, and genetic polymorphisms as risk factors for colorectal cancer. Results of the study can be referred to make policy for colorectal cancer prevention programs in Indonesia as well as a reference to design effective treatments of colorectal cancer patients in Indonesia.
Description: Oral presentation in the 47th Asia Pacific Consortium for Public health Conference, 21-23 October 2015, Bandung, Indonesia
URI: http://repository.uinjkt.ac.id/dspace/handle/123456789/32058
ISBN: 978-602-19562-5-4
Appears in Collections:Prosiding Workshop/Lokakarya/Seminar

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